I didn't see anything about this on the Israel PTO's web site, but from the Patents Journal that published on February 1, I see that Israel hit patent application no. 300,000 on January 16, 17 or 18. Patent applications in Israel are numbered sequentially and stay the same once a patent is granted, and since not all applications proceed to grant, this means that we're still at fewer than 300K granted patents. Still, 300,000 applications is a respectable milestone.
To get a sense of timing, application no. 75,100 was filed in May 1985 (before Israel joined the PCT), no. 100,000 was filed in November 1991, no. 125,000 in June 1998 (after Israel joined the PCT), no. 150,000 in June 2002, no. 175,000 in April 2006, no. 200,000 in July 2009, no. 225,000 in September 2011, no. 250,000 in January 2017, and no. 275,000 in May 2020. Most of those applications were all filed as national phase applications of PCT filings, and consequently in the ILPTO's database their filing dates are listed as the PCT filing date rather than the national phase date, but the application number accords with the date of national phase entry.