An applicant who is entitled to file a PCT application may file using his "home" patent office as the PCT Receiving Office (RO), or, if local law allows filing outside the "home" jurisdiction, at the PCT International Bureau (IB). (Technically, one may actually file at ANY PCT RO, but if it's not one's "home" RO or the IB, additional fees may be required.)
For many reasons, I am a fan of filing via ePCT, using the IB as the RO. Among those reasons: ePCT includes many checks to help ensure that you don't miss a date or omit materials; ePCT allows you to see what your drawings will look like before they're submitted; after filing, you can immediately check on the application in your ePCT "workbench"; and if there are problems, you can talk to the people at the RO/IB, which is super, super helpful and which, like the rest of the electronic filing team at the IB, super super responsive.
(To give fair due to the PCT section of the Israel PTO: they are also a super helpful crew. Unfortunately, at present if one files at RO/IL, it takes a few days until the application shows up in ePCT.)
From time to time, the IB offers free webinars on the PCT in general, on using ePCT, on using the PatentScope database, and on other topics. On October 14 it offered a seminar that included updates on PCT rules and some other helpful information. There was also a presentation on e-filing using ePCT, which was good for people who haven't used the system before (although unnecessary for those who have). The question-and-answer session at the end also contained useful information. The session will be offered again live on October 28 and November 2 (click here to register), but the October 14 session has already been archived and available for listening here. I highly recommend that readers go to 1:39:00 and listen for the next minute: the IB knows it's super helpful...and that not all RO's are as inclined to help applicants.